Postmenopausal Hormone Therapy: Knowledge and Recommendations
Kernaussagen der Interdisziplinären S3-Leitlinie Hormontherapie (HT) in der Peri- und Postmenopausegerman translation / full article
Key-Messages of the Interdisciplinary German Guideline on Hormone Therapy (HT) during Peri- and Postmenopause
Background: In Germany an increasing number of interdisciplinary guidelines aiming at a high methodological level have been developed.
Methods: An interdisciplinary working group of German colleges including a Family Practitioner and patients advocacy groups developed a guideline for peri- and postmenopausal hormonal therapy (HT) which was published in 2009. The key-messages as well as some background information, further evaluations and new important information (published after the deadline for studies contributing to the guideline) are reported. The table constructed for the guideline contains information about numbers-needed-to-treat and numbers-needed-to-harm derived from large randomized controlled trials.
Results: HT is useful for treatment of hot flushes and vaginal dryness which show an increased prevalence in this period of life. Probatory use is justified for recurrent urinary-tract infections. Although all forms of administration are effective, local application should be preferred for urogenital symptoms. HT is not indicated for cardiovascular prevention and offers only a second-line prophylactic treatment for osteoporosis.
Conclusions: Before starting HT and during HT administration benefits and risks (especially breast cancer, thromboembolic events, strokes and diseases of the biliary tract) have to be considered carefully. Due to lack of data alternative (complementary) treatment options cannot be recommended