Non-Toxic Thyroid Nodules: Benefit/Harm of Levothyroxine
Non-Toxic Thyroid Nodules: Benefit/Harm of Levothyroxinegerman translation / full article
What is the benefit or potential harm of levothyroxine suppressive therapy in the treatment of patients with benign, non-toxic thyroid nodules?
Levothyroxine suppressive therapy is not recommended for euthyroid patients with benign thyroid nodules without symptoms because reduction of the nodule volume only constitutes a surrogate parameter of questionable clinical relevance. Moreover, potential adverse effects of long-term treatment such as the risk of cardiovascular events like atrial fibrillation or tachycardia, osteoporosis and iatrogenic hyperthyroidism must be considered.