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Acetylsalicylic Acid in Prevention of Colorectal Carcinoma

german translation / full article

Giuliano Piccoliori, Andreas Sönnichsen

Question

Should a 52 year old man with a first grade positive family history for colorectal carcinoma take low dose ASS daily for cancer prevention?

Answer

ASS reduces incidence and specific mortality of colorectal cancer. At the same time it increases bleeding risk, especially in the gastointestinal tract. Current best evidence points at a probable net-benefit of daily ASS for middle aged men and women with elevated cardiovascular risk regarding cardiovascular risk and colorectal cancer in primary prevention. The decision to take low dose ASS daily in primary prevention should therefore be based on an individual decision making process taking cardiovascular risk into account. It is conceivable that men and women with a positive family history for colorectal cancer may benefit more from daily ASS, but currently there is no study evidence backing this assumption.


(State: 15.11.2017)

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